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Dectromethorphan : from cough suppressant to antidepressant

Material type: Text

TextPublication details: Thorofarem Jersey : Slack Incorporated, 2022Description: Vol. 60 (11) : pages 9-11Uniform titles:

Journal of psychosocial nursing and mental health services / November 2022

List(s) this item appears in: Periodical index

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Dextromethorphan (DXM) has been repurposed several times over the past 7 decades: first as a cough suppressant, then as a compounded formulation with quinidine for treatment of pseudobulbar affect, and most recently as a compounded formulation with bupropion for treatment of major depressive disorder. The current article describes the history and purported mechanisms of action of DXM for each use and the uniquely rapid action and safety profile of the oral dextromethorphanbupropion antidepressant formulation.

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