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Dextromethorphan : From cough suppressant to antidepressant / Karan Kverno

By: Material type: TextTextDescription: Vol 60 (11) pages 9-11 : illustrations ; 27 cmUniform titles:
  • Journal of Psychosocial Nursing and Mental Health Services / November 2022
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ABSTRACT

Dextromethorphan (DXM) has been repurposed several times over the past 7 decades: first as a cough suppressant, then as a compounded formulation with quinidine for treatment of pseu-dobulbar affect, and most recently as a compounded formulation with bupropion for treatment of major depressive disorder. The current article describes the history and purported mechanisms of action of DXM for each use and the uniquely rapid action and safety profile of the oral dextromethorphan-bupropion antidepressant formulation.
[Journal of Psychosocial Nursing and Mental Health Services, 60(11), 9-11.]

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